Idiopathic normal pressure hydrocephalus. Retrospective review of pathogenesis and modern theories

  • G.V. Gavrilov Military Medical Academy named after S.M. Kirov "Ministry of Defense of the Russian Federation, St. Petersburg. https://orcid.org/0000-0002-8594-1533
  • Artem V. Stanishevskiy Military Medical Academy named after S.M. Kirov "Ministry of Defense of the Russian Federation, St. Petersburg. https://orcid.org/0000-0002-2615-269X
  • B.V. Gaydar Military Medical Academy named after S.M. Kirov "Ministry of Defense of the Russian Federation, St. Petersburg.
  • D.V. Svistov Military Medical Academy named after S.M. Kirov "Ministry of Defense of the Russian Federation, St. Petersburg. https:/orcid.org/ 0000-0002-3922-9887
DOI: https://doi.org/10.25557/0031-2991.2020.03.146-155
Keywords: normal pressure hydrocephalus, pathogenesis, pathophysiology, CSF circulation, neurodegenerative disease

Abstract

Idiopathic normal pressure hydrocephalus is a chronic, progressive degenerative brain disease characterized by ventricular enlargement disproportionate to other cerebrospinal fluid (CSF) spaces with normal CSF pressure. This disease presents with gait disturbance, cognitive impairment, and incontinence. The pathophysiology and morphogenesis of this condition are not well studied. Since the first description by S. Hakim in 1964, a number of experimental and morphological studies have focused on investigation of the disease mechanisms. This review retrospectively analyzed and summarized principal ideas about the pathogenesis of idiopathic normal pressure hydrocephalus.

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Published
2020-08-21
How to Cite
Gavrilov G., Stanishevskiy A. V., Gaydar B., Svistov D. Idiopathic normal pressure hydrocephalus. Retrospective review of pathogenesis and modern theories // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2020. VOL. 64. № 3. PP. 146–155.
Issue
Vol. 64 No. 3 (2020)
Section
Reviews