Protection of the liver by oxymethyluracil and derivatives of succinic acid at influence of tetrachlormethane in the experiment

Abstract

The effect of a new complex compound "oxymethyluracil + sodium succinate" on the morphological state and AOS of the liver damaged by tetrachloride has been studied using 50 experimental white male rats,. Purpose. Comparative assessment of hepatoprotective properties of the "oxymethyluracil + sodium succinate" compound with OMU and sodium succinate using the experimental model of acute toxic damage of the liver induced by TCR. Results. The complex compound studied has been shown to produce maximal hepatoprotective effects at a dose of 50 mg/kg through limiting TCR necrosogenic effect, preserving metabolic activity of the liver due to beneficial effects of enzymes (urokaninase, AcAT, ЩФ), levels of bilirubin and triglycerides as well as the POL-AOS system (DK, TK, SOD, KAT), reduced glutathione, SH-group levels. In the rat groups, with oxymethyluracil and sodium succinate administered separately at a dose of 25 mg/kg for treatment and prevention, POL-AOS functioning has also been normalized, while the liver functional activity and its morphological structure – to a lesser degree. Conclusion. The usefulness of simultaneous administration of oxymethyluracil and sodium succinate is confirmed by a higher survival rate of the rats which received the complex compound "oxymethyluracil + sodium succinate" in case of poisoning with TCR at a lethal dose.