Institute of General Pathology and Pathophysiology RAMS, 8 Baltiyskaya str., Moscow, 125315, Russia

  • R.V. Karpova Blokhin N.N.Russian Cancer Research Center RAMS, 24, Kashirskoye sh., Moscow, 115478, Russia
  • E.V. Bocharov The purpose of the work was to elucidate the radioprotective efficacy of multyphytoadaptogene (MPA) in dogs in various conditions of gamma radiation and MPA application. Dogs were given 15% MPA solution with drinking water in 3,6 ml/kg dose per day 2 weeks before the radiating (preventive application), 2 weeks before and 2 weeks after the radiating (preventive and therapeutic application) as well as 2 weeks after the radiating only (therapeutic application). Animals of control groups received radiation. Dogs were exposed to 3,5 Gy acute radiation and 8,0 Gy prolonged radiation. There were no survived dogs in control groups. At the same time MPA increased dogs survival in preventive, preventive and therapeutic as well as therapeutic applications after 3,5 Gy acute radiation and after 8,0 Gy prolonged radiation. MPA improved the somatic state, interfere with leukocytes amount in blood. The data obtained suggest the radioprotective efficacy of MPA.
  • I.V. Kazeev Blokhin N.N.Russian Cancer Research Center RAMS, 24, Kashirskoye sh., Moscow, 115478, Russia
  • V.G. Kucheryanu The purpose of the work was to elucidate the radioprotective efficacy of multyphytoadaptogene (MPA) in dogs in various conditions of gamma radiation and MPA application. Dogs were given 15% MPA solution with drinking water in 3,6 ml/kg dose per day 2 weeks before the radiating (preventive application), 2 weeks before and 2 weeks after the radiating (preventive and therapeutic application) as well as 2 weeks after the radiating only (therapeutic application). Animals of control groups received radiation. Dogs were exposed to 3,5 Gy acute radiation and 8,0 Gy prolonged radiation. There were no survived dogs in control groups. At the same time MPA increased dogs survival in preventive, preventive and therapeutic as well as therapeutic applications after 3,5 Gy acute radiation and after 8,0 Gy prolonged radiation. MPA improved the somatic state, interfere with leukocytes amount in blood. The data obtained suggest the radioprotective efficacy of MPA.
  • O.A. Bocharova Blokhin N.N.Russian Cancer Research Center RAMS, 24, Kashirskoye sh., Moscow, 115478, Russia
Keywords: понденции: Карпова Регина Васильевна, канд. Биол. наук, ст. науч. сотр. лаб. иммунофармакологии ФГБУ «РОНЦ им. Блохина Н.Н.» РАМН. E-mail: planta39@rambler.r

Abstract

Keywords: ionizing radiation, multiphytoadaptogen, anti-radiation efficacy.

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Published
2013-11-29
How to Cite
Karpova R., Bocharov E., Kazeev I., Kucheryanu V., Bocharova O. Institute of General Pathology and Pathophysiology RAMS, 8 Baltiyskaya str., Moscow, 125315, Russia // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2013. VOL. 57. № 4. PP. 51–54.
Issue
Vol. 57 No. 4 (2013)
Section
Original research