The participation of matrix metalloproteinases-9 and TIMP-1 in formation of atrial fibrillation paroxisms in patients with metabolic syndrome

  • V.A. Akhmedov Omsk state medical academy, 12, Lenina str., Omsk, 644043, Russia
  • V.T. Dolgikh Omsk state medical academy, 12, Lenina str., Omsk, 644043, Russia
  • D.V. Naumov Clinical Hospital of Omsk Passazhirsky station, 41, Karbyshev str., Omsk, 644099, Russia
  • N.A. Nechiporenko Clinical Hospital of Omsk Passazhirsky station, 41, Karbyshev str., Omsk, 644099, Russia
Keywords: MMP-9, TIMP-1, atrial fibrillation, metabolic syndrome, gene polymorphism

Abstract

The aim of this study was to estimate the role of matrix metalloproteinases activity (MMP-9, TIMP-1) and gene polymorphism at the patients with metabolic syndrome in combination with paroxysmal form of atrial fibrillation. The 60 patients with metabolic syndrome in combination with paroxysmal form of atrial fibrillation were investigated with estimation of serum levels of MMP-9, TIMP-1 and mutation of genes of angiotenzinogen 1 Thr 174 Met, angiotenzinogen 2 Met 235 Thr and apolipoprorein C3 C3238 G. In patients with metabolic syndrome in combination with paroxysmal form of atrial fibrillation the significant increase synthesis of MMP-9 level can lead to increase of atrial fibrillation paroxysms because of increase synthesis of collagen tissue in myocard and vessel walls. Also the significant high incidence of angiotenzinogen 2 Met 235 Thr mutation was established.

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Published
2013-11-29
How to Cite
Akhmedov V., Dolgikh V., Naumov D., Nechiporenko N. The participation of matrix metalloproteinases-9 and TIMP-1 in formation of atrial fibrillation paroxisms in patients with metabolic syndrome // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2013. VOL. 57. № 4. PP. 46–50.
Issue
Vol. 57 No. 4 (2013)
Section
Original research