Молекулярно-генетические механизмы формирования очагов гетеротопической оссификации

Ivan A. Stepanov; V.A. Beloborodov; M.A. Shameeva

doi:10.25557/0031-2991.2020.02.102-110

Ivan A. Stepanov Irkutsk State Medical University, Ministry of Health, 1, Krasnogo Vosstaniya Str., Irkutsk, 664003, Russia; Kharlampiev Clinic, 8, Gorkogo Str., Irkutsk, 664025, Russia https://orcid.org/0000-0001-9039-9147
V.A. Beloborodov Irkutsk State Medical University, Ministry of Health, 1, Krasnogo Vosstaniya Str., Irkutsk, 664003, Russia https://orcid.org/0000-0002-3299-1924
M.A. Shameeva Irkutsk State Medical University, Ministry of Health, 1, Krasnogo Vosstaniya Str., Irkutsk, 664003, Russia https://orcid.org/0000-0002-3085-2998

DOI: https://doi.org/10.25557/0031-2991.2020.02.102-110

Keywords: heterotopic ossification, molecular mechanisms, bone morphogenetic proteins, intracellular signaling pathways, nonsteroidal anti-inflammatory drugs, retinoic acid receptor agonists, free radical scavengers, radiotherapy, prevention

Abstract

This review addressed molecular and genetic mechanisms of heterotopic ossification (HO). HO is a process of lamellar bone formation in soft tissues lacking osteogenic properties. Several intracellular signaling pathways for differentiation of mesenchymal stem cells along with the osteogenesis pathway play an important role in the pathogenesis of HO formation. This review analyzed experimental studies of HO molecular mechanisms. The authors presented state-of-the-art information about molecular therapeutic approaches in HO treatment and prevention and identified relevant but still unresolved issues, which warrant further experimental and clinical studies.

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Molecular and genetic mechanisms of heterotopic ossification

Abstract

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