Effects of intravenous administration liposomal form of acetylcysteine on the functional state respiratory system in rats with acute lung injury

Abstract

The purpose. We studied the influence of a single intravenous injection of liposomal form of acetylcysteine (NAC) on respiratory function in rats with acute lung injury. Methods. Liposomal form acetylcysteine was obtained from lecithin and cholesterol; acetylcysteine was implemented into liposomes by passive loading. The total dose of NAC in experimental animals was 25 mg/kg. The study was conducted in a comparative aspect. Therapy comparison is a single intravenous injection of dexamethasone at a dose of 6 mg/kg. Model of acute lung injury was a single intratracheal administration of acetone at a dose of 0,1 ml/kg. Results. The study showed that liposomal acetylcysteine and drug comparison — dexamethasone are effective in reducing mortality in acute lung injury. The survival of experimental animals in the 1 st day after acute lung injury was highest when using liposomal NAC. Intravenous injection of liposomal NAC leads to an increase of oxygenation of blood the rats over a 6-day post-injection. Dexamethasone effective than liposome form of NAC increases the hemoglobin oxygen saturation at 24 hours after intravenous administration. Intravenous dexamethasone is effective in reducing the degree of pulmonary edema 24 hours after modeling pathology. Introduction liposomes NAC reduces the severity of pulmonary edema in rats on the 1st and 6th day after modeling acute lung injury. Liposomal NAC effective than dexamethasone prevents the development of pulmonary edema after 6 days in acute lung injury. After administration of liposomes NAC spirogram indices in rats to a greater extent close to the original values than after administration of dexamethasone. Conclusion. Compared with the single administration of dexamethasone, liposomal acetylcysteine no less effective for exogenous acute lung injury, as a means of improving the function of the respiratory system and means of reducing mortality.