Pathogenetic evaluation of immunologic reactivity in crush syndrome

  • M. Z. Saidov Dagestan State Medical University, Machachtkala
  • A. A Dalgatova Dagestan State Medical University, Machachtkala
  • K. Z. Kurbanov Dagestan State Medical University, Machachtkala
  • A. U. Gamzaeva Dagestan State Medical University, Machachtkala
Keywords: crush syndrome, endotocsemia, lymphocytes, soluble levels CD3G, CD19, TNF-a, IL-6, IF-g, cortisol, pathomorphology lymphoid organs.

Abstract

The purpose. Pathogenesis evaluation of adaptive immune system and immunomorphology lymphoid organs in experimental crush syndrome. Methods. crush syndrome I, II и III stage of hard was modeling by injury-crushing on 2, 4 и 6 houres after limb compression in rats. The level of solube CD3G, CD19, TNF-a, IL-6 and IF-g was measuring by IEA methods. The pathomorphologic changes was evaluated on histologic slides. Results. It was shown that compression trauma induces multi-system changes including endotocsemia, hyperproduction of proinflammatory cytokines TNF-a, IL-6, IF-g and cortisol, high serum levels of soluble CD3G and CD19, intensive changes of structural and functional changes in lymphoid organs. Conclusion. The results obtained were shown the intensive changes of adaptive immune systems including stress reaction and hypercortisolemia.

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Published
2017-01-10
How to Cite
Saidov M. Z., Dalgatova A. A., Kurbanov K. Z., Gamzaeva A. U. Pathogenetic evaluation of immunologic reactivity in crush syndrome // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2017. VOL. 61. № 1. PP. 65–71.
Issue
Vol. 61 No. 1 (2017)
Section
Original research