Integrated assessment of serum homeostasis shifts in experimental myocardial infarction

  • M. A. Lebedeva The Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia; SF Institute of Pharmacology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • U. S. Medvedeva The Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • R. S. Mirzoyan SF Institute of Pharmacology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • D. V. Maslennikov SF Institute of Pharmacology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • N. N. Zolotov SF Institute of Pharmacology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • M. Yu. Karganov The Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia; A.N. Bach Institute of Biochemistry of the RAS, Leninsky prospekt, 33, build. 2, Moscow, 119071, Russia
Keywords: experimental myocardial infarction, lactate dehydrogenase, laser correlation spectroscopy, homeostasis

Abstract

Dynamic changes in serum homeostasis of rats with experimental myocardial infarction evolution using the method of laser correlation spectroscopy were studied. The presence of necrotic myocardial damage was confirmed by electrocardiographic, histological and biochemical methods. Increased contribution of small particles in the acute period of myocardial infarction was detected, which indicates products of catabolism accumulation in serum and changing the level of some proteins. Comparison of subfractional content of sera from rats with varying degrees of extension of myocardial necrosis through the ventricular wall revealed the predominance of particles of low molecular size (up to 10 nm) in animals with transmural infarction and middle-size fraction (50—120 nm) in animals with non-transmural infarction. These results are consistent with the clinical data obtained by this method in patients with Q-wave and non-Q-wave myocardial infarction.

Downloads

Download data is not yet available.
Published
2013-11-29
How to Cite
Lebedeva M. A., Medvedeva U. S., Mirzoyan R. S., Maslennikov D. V., Zolotov N. N., Karganov M. Y. Integrated assessment of serum homeostasis shifts in experimental myocardial infarction // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2013. VOL. 57. № 4. PP. 35–40.
Issue
Vol. 57 No. 4 (2013)
Section
Original research