The effect of metformin on myocardial tolerance to ischemia in rats with Diabetes mellitus type 2

  • Е. N. Кravchuk Almazov Federal Heart, Blood and Endocrinology Centre, 2 Akkuratova str., St. Petersburg, 197341, Russia
  • Е. N. Grineva Almazov Federal Heart, Blood and Endocrinology Centre, 2 Akkuratova str., St. Petersburg, 197341, Russia
  • М. М. Galagudza Almazov Federal Heart, Blood and Endocrinology Centre, 2 Akkuratova str., St. Petersburg, 197341, Russia; I.P. Pavlov State Medical University, 6/9, Lva Tolstogo street, St. Petersburg, 197089, Russia
  • А. А. Bairamov Almazov Federal Heart, Blood and Endocrinology Centre, 2 Akkuratova str., St. Petersburg, 197341, Russia
Keywords: diabetes mellitus type 2, biguanides, metformin, infarct size, metabolic preconditioning

Abstract

The effect of metformin on myocardial sensitivity to ischemia in rats with neonatal streptozotocin T2DM was investigated using the model of global ischemia-reperfusion in the isolated perfused heart. Metformin administration had no effect on infarct size. At the same time, infarct size in T2DM was significantly lower than in controls, which is indicative of the phenomenon of metabolic preconditioning in T2DM. The protocol of metformin administration used in this study had not afforded a significant cardioprotective effect in animals with T2DM.

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Published
2013-11-29
How to Cite
Кravchuk Е. N., Grineva Е. N., Galagudza М. М., Bairamov А. А. The effect of metformin on myocardial tolerance to ischemia in rats with Diabetes mellitus type 2 // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2013. VOL. 57. № 4. PP. 32–34.
Issue
Vol. 57 No. 4 (2013)
Section
Original research