The resistance of low brainstem tissue to free radical oxidation in rats during periodic breathing following hydroxybutyrate treatment

  • I. A. Tarakanov Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • L. N. Tikhomirova Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • A. G. Zhukova Institute for Complex Problems of Hygiene and Occupational Diseases SB RAMS, 23, Kutuzov street, Novokuznetsk, 654041
  • V. A. Safonov Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
Keywords: respiratory center, resistance to free radical oxidation, periodic breathing, hydroxybutyrate, rat

Abstract

We evaluated tissue resistance to free radical oxidation, in pentobarbital-anesthetized mongrel albino male rats during pathologic periodic breathing following hydroxybutyrate (GHBA) administration. It was shown that GHBA modulated pro- and antioxidant status of brain tissue. In the absence of periodic breathing after GHBA, decreases in resistance of brainstem tissue membranes to induction of free radical oxidation were slightly pronounced. Rats with GHBA-induced periodic breathing exhibited increased membrane sensitivity of medullar neurons to induction of free radical oxidation. We suggest that cellular metabolism and/or membrane mechanisms of respiratory rhythm-generating neurons play a role in the pathogenesis of periodic breathing.

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Published
2013-11-29
How to Cite
Tarakanov I. A., Tikhomirova L. N., Zhukova A. G., Safonov V. A. The resistance of low brainstem tissue to free radical oxidation in rats during periodic breathing following hydroxybutyrate treatment // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2013. VOL. 57. № 4. PP. 21–25.
Issue
Vol. 57 No. 4 (2013)
Section
Original research