Morphological study of neuroprotective properties of dipeptide mimetic of nerve growth factor (GK-2h) in focal ischemic damage of rat brain prefrontal cortex

  • I. V. Barskov Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • E. V. Stelmashuk Research Center of Neurology RAMS, 80, Volokolamskoye hwy., Moscow, 125367, Russia
  • G. A. Romanova Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • L. G. Khaspekov Research Center of Neurology RAMS, 80, Volokolamskoye hwy., Moscow, 125367, Russia
Keywords: nervous growth factor mimetic, bifocal photoinduced ischemia, rat brain prefrontal cortex, neuroprotection

Abstract

The neuroprotective effects of dipeptide GK-2h, a mimetic of nerve growth factor, in bifocal photoinduced ischemia in rat brain prefrontal cortex was studied. It was shown that GK-2h, injected intraperitonealy in dose 0,1 mg/kg in 1 h or 4 h after operation and then on 2-nd, 4-th and 8-th days, prevented significantly on 9-th day from increasing volume of cortical infarction.

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Published
2013-11-29
How to Cite
Barskov I. V., Stelmashuk E. V., Romanova G. A., Khaspekov L. G. Morphological study of neuroprotective properties of dipeptide mimetic of nerve growth factor (GK-2h) in focal ischemic damage of rat brain prefrontal cortex // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2013. VOL. 57. № 4. PP. 17–20.
Issue
Vol. 57 No. 4 (2013)
Section
Original research