Влияние Семакса на активность сукцинатдегидрогеназы митохондрий мозга при экспериментальном двустороннем фотохимическом ишемическом повреждении префронтальной коры

Fatima M. Shakova; Y. I. Kirova; G. A. Romanova

doi:10.25557/0031-2991.2018.04.257-260

The influence of Semax on the activity of brain mitochondria succinate dehydrogenase in experimental bilateral photochemical ischemic damage to the prefrontal cortex

Fatima M. Shakova FSBI Institute of General Pathology and Pathophysiology, 8, Baltiyskaya str., 125315, Moscow, Russia
Y. I. Kirova FSBI Institute of General Pathology and Pathophysiology, 8, Baltiyskaya str., 125315, Moscow, Russia
G. A. Romanova FSBI Institute of General Pathology and Pathophysiology, 8, Baltiyskaya str., 125315, Moscow, Russia

DOI: https://doi.org/10.25557/0031-2991.2018.04.257-260

Keywords: ischemia, succinate dehydrogenase, photothrombosis, Semax, prefrontal cortex

Abstract

Ischemic damage to the prefrontal cortex is accompanied by early and progressive decrease in the succinate dehydrogenase (SDH) activity of the mitochondria of the perifocal area. The daily fractional administration of a synthetic analogue of the ACTH4-10 fragment — Semax at a dose of 25 µg / kg is accompanied by normalization of the activity of SDH 24 hours after photothrombosis of the cortex. The study showed that the determination of the activity of SDH is an informative method to assess the severity of ischemic brain damage and the effectiveness of neuroprotective therapy.

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Published

2018-11-21

How to Cite

Shakova F. M., Kirova Y. I., Romanova G. A. The influence of Semax on the activity of brain mitochondria succinate dehydrogenase in experimental bilateral photochemical ischemic damage to the prefrontal cortex // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2018. VOL. 62. № 4. PP. 257–260.