Neurobiological predisposition to addictive disorders. Antibodies to neurotransmitters

Abstract

Identification of neurobiological susceptibility to addictive disorders is an important issue of preventing psychoactive substance dependence. A key role in approaching this issue belongs to studying molecular neuroimmune mechanisms for neurotransmission regulation during development of addictive disorders. The aim of this study was to construct a pattern of changes in serum neurotransmitter autoantibodies during formation of psychoactive substance dependence using immunoassay. The system of antibodies to dopamine, norepinephrine, and glutamate changed during the development of psychoactive substance dependence and can be considered as a neuroimmune marker for identifying groups at risk of drug addiction.