The effect of S100B deficit in early ontogenesis on behavior of adult animals in the open field test

  • Alexander V. Lobanov Institute of General Pathology and Pathophysiology, Baltijskaya Str. 8, Moscow 125315, Russian Federation; Branch of the M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Prospekt Nauki 6, Pushchino of Moscow Region 142290, Russian Federation
  • D. M. Davydov Institute of General Pathology and Pathophysiology, Baltijskaya Str. 8, Moscow 125315, Russian Federation
  • N. A. Perepechenova Branch of the M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Prospekt Nauki 6, Pushchino of Moscow Region 142290, Russian Federation
  • O. L. Cherkashina M.V. Lomonosov Moscow State University. Leninskie Gory 1, Moscow 119991, Russian Federation
  • N. S. Karpova M.V. Lomonosov Moscow State University. Leninskie Gory 1, Moscow 119991, Russian Federation
  • I. A. Zakharova Institute of General Pathology and Pathophysiology, Baltijskaya Str. 8, Moscow 125315, Russian Federation
  • S. G. Morozov Institute of General Pathology and Pathophysiology, Baltijskaya Str. 8, Moscow 125315, Russian Federation
DOI: https://doi.org/10.25557/0031-2991.2018.04.246-249
Keywords: S100B protein, immunization, behavior, mice

Abstract

Earlier it was shown that the shortage of S100B protein in early ontogenesis affected formation of the behavioral phenotype in mice during the nesting period of development. This study focused on effects of S100B protein deficiency induced by immunization of female mice on behavior of their offspring at the age of 12 months in the open field. The motor and exploratory activity of females was increased whereas the activity of males born from immunized animals was decreased compared to the control. Also, normal sexual dimorphism of the open field behavior characteristic of 12-month old control ICR mice was lost.

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Published
2018-11-21
How to Cite
Lobanov A. V., Davydov D. M., Perepechenova N. A., Cherkashina O. L., Karpova N. S., Zakharova I. A., Morozov S. G. The effect of S100B deficit in early ontogenesis on behavior of adult animals in the open field test // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2018. VOL. 62. № 4. PP. 246–249.
Issue
Vol. 62 No. 4 (2018)
Section
Brief Reports