Administration of extracellular vesicles from bone marrow cells promotes recovery of physiological parameters in irradiated mice

Abstract

Extracellular vesicles secreted by human multipotent mesenchymal stromal cells were injected intravenously into mice one week after irradiation at a sublethal dose. At 3 and 6 weeks after the start of the experiment, changes in physiological parameters provoked by the irradiation and therapy were evaluated. The following methods of evaluation were used: measurement of body weight, laser correlation spectroscopy, white blood cell count, laser flow cytometry, histological examination of internal organs. The study showed that a single intravenous injection of the analyzed extracellular vesicles into irradiated animals helped to reduce severity of the changes caused by a high dose of gamma radiation.