Role of inflammation cytokines in forming and rupture of brain arterio-venous malformations

Abstract

This review analyzes current reports on the pathogenetic role of inflammatory cytokines in formation and rupture of cerebral arteriovenous malformations (cAVM). The authors analyzed reports from PubMed, MedLine, and eLibrary databases that addressed the role of inflammatory cytokines in the molecular pathogenesis of cAVM formation and rupture. The cAVM rupture leading to intracranial hemorrhage is the most frequent and formidable clinical manifestation resulting in persistent neurologic deficits, early disability, and death. In the pathogenesis of cAVM development, an important role belongs to the inflammatory process, which induces thinning of the vascular wall. Relationships were found between some genetic polymorphisms that enhance expression of a number of angiogenic and proinflammatory factors that play a key role in the