Therapy with directed depo-transportation drug the urethra`s erosion after setting the suburethral mesh

Abstract

Background. Formed erosions of urethra after setting suburethral mesh (SM) by stress urinary incontinence (SUI) at women could be accompanied by dysuria and demand the therapeutic correction. The complex preparations with directed depot-transportation have a good potential for treatment this kind of mesh-associated complication. Objective. To study the efficiency of using the complex preparation with possibility of directed depot-transportation for medications, for example hydrogel material of sodium alginate with dioxidine and lidocaine (HMSADL) as complex with anesthetic and antibiotic, for treatment of urethra`s erosion after setting SM by SUI. Methods. By 78 female patients, with vindicated in urethrascope urethra’s erosion after setting the SM, was studied the dysuria syndrome and efficiency of locally transvaginal treatment with HMSADL and without HMSADL. There was performed the analysis the two groups of patients with different methods of treatment. Results. The results of treatment of dysuria (29% before treatment, 3,2% after) and urethra’s erosion (3,2% after treatment) were statistically significantly better in the patients’ group, in which were used locally transvaginal HMSADL, as in the group, where the local therapy HMSADL was not used (dysuria — 23,1% before treatment and 19% after, erosion — 36,1% after treatment). It was proved also urine’s analysis. There were less patients after treatment with high level of erythrocytes or leucocytes in urine in the group with local treatment by HMSADL 12,1% against 46,8% in the group without local therapy. Conclusion. Using the polypropylene material at setting SM by SUI is accompanied by urethra’s reaction on foreign substance and compression of urethra’s wall, it manifests with dysuria and urethra’s erosion. It allows, accounting the anatomical closeness urethra and anterior wall of vagina, but also development of preparations of directed depot-transportation in complex with others medications, to use these complex preparations, such as HMSADL, for treatment the urethra’s erosion and dysuria.