Agoniists of opioid receptors may aggravate ischemic and reperfusion damages of the heart

  • L. N. Maslov Federal State Budgetary Institution «Research Institute for Cardiology» of Siberian Branch under the Russian Academy of Medical Sciences
  • E. I. Barzakh Federal State Budgetary Institution «Research Institute for Cardiology» of Siberian Branch under the Russian Academy of Medical Sciences
  • A. Yu. Lishmanov Federal State Budgetary Institution «Research Institute for Cardiology» of Siberian Branch under the Russian Academy of Medical Sciences
  • A. S. Gorbunov Federal State Budgetary Institution «Research Institute for Cardiology» of Siberian Branch under the Russian Academy of Medical Sciences
  • S. Yu. Tsybulnikov Federal State Budgetary Institution «Research Institute for Cardiology» of Siberian Branch under the Russian Academy of Medical Sciences
  • A. S. Sementsov Federal State Budgetary Institution «Research Institute for Cardiology» of Siberian Branch under the Russian Academy of Medical Sciences
Keywords: heart, ischemia, reperfusion, opioid receptors, infarct size, arrhythmias

Abstract

Authors analyzed articles that opioids may aggravate ischemic and reperfusion damages of the heart but the opioid receptor antagonists may prevent these damages. Authors concluded the it is existed opioid receptor pool an activation of its decreases cardiac tolerance to an impact of ischemia-reperfusion.

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Published
2014-02-03
How to Cite
Maslov L. N., Barzakh E. I., Lishmanov A. Y., Gorbunov A. S., Tsybulnikov S. Y., Sementsov A. S. Agoniists of opioid receptors may aggravate ischemic and reperfusion damages of the heart // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2014. VOL. 58. № 1. PP. 79–84.
Issue
Vol. 58 No. 1 (2014)
Section
Reviews