Effect of the alloxane diabetes on the cardio-vascular system function and lipid peroxidation in rats of different genetic strains

  • E. A. Smirnova Federal State Budgetary Institution «Institution of General Pathology and pathophysiology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8; Federal State Budgetary Institution «Institution of Pharmacology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8
  • O. L. Terekhina Federal State Budgetary Institution «Institution of General Pathology and pathophysiology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8; Federal State Budgetary Institution «Institution of Pharmacology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8
  • D. D. Matzievski Federal State Budgetary Institution «Institution of General Pathology and pathophysiology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8; Federal State Budgetary Institution «Institution of Pharmacology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8
  • T. A. Antipova Federal State Budgetary Institution «Institution of General Pathology and pathophysiology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8; Federal State Budgetary Institution «Institution of Pharmacology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8
  • L. P. Kobozeva Federal State Budgetary Institution «Institution of General Pathology and pathophysiology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8; Federal State Budgetary Institution «Institution of Pharmacology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8
  • A. B. Michunskaya Federal State Budgetary Institution «Institution of General Pathology and pathophysiology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8; Federal State Budgetary Institution «Institution of Pharmacology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8
  • O. M. Pozdnyakov Federal State Budgetary Institution «Institution of General Pathology and pathophysiology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8; Federal State Budgetary Institution «Institution of Pharmacology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8
  • S. V. Kruglov Federal State Budgetary Institution «Institution of General Pathology and pathophysiology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8; Federal State Budgetary Institution «Institution of Pharmacology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8
  • L. Yu. Bakhtina Federal State Budgetary Institution «Institution of General Pathology and pathophysiology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8; Federal State Budgetary Institution «Institution of Pharmacology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8
  • L. M. Belkina Federal State Budgetary Institution «Institution of General Pathology and pathophysiology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8; Federal State Budgetary Institution «Institution of Pharmacology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8
Keywords: diabetes 1, alloxane, heart contractile function, microvessels, lipid peroxidation, nitric oxide

Abstract

We have previously shown that the innate increased activity of the NO- system, typical for the August rats, increases vulnerability to alloxane diabetes (ALD). The purpose of this study was to investigate the effect of ALD on the cardio-vascular system and lipid peroxidation in rats with different activity of NO-system. The August rats and Wistar rats treated with alloxan (125 mg / kg, s/c, once) were studied 3.5 months after. In August-ALD the double production significantly decreased to a greater extent (by 35%) than in Wistar-ALD (by 17% ) compared with the control. As in August-ALD and in Wistar-ALD was observed the similar fall of the relaxation (-dp/dt) of the left ventricle (by 45-49%), but not the contraction rate (+dp/dt). LPO activation in the heart and liver, as well as NO-system (level of nitrates and nitrites in the blood plasma) in August rats were more pronounced than in Wistar rats. The hsp32 level in August rats fell significantly more (by 93% ) than in Wistar rats (by 61 %). Pathological changes in the microvasculature of the mesostenium were identical in compared rats. Thus , more pronounced cardiac dysfunction in August-ALD, compared with Wistar-ALD, associated with greater activation of lipid peroxidation and NO-system.

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Published
2014-02-03
How to Cite
Smirnova E. A., Terekhina O. L., Matzievski D. D., Antipova T. A., Kobozeva L. P., Michunskaya A. B., Pozdnyakov O. M., Kruglov S. V., Bakhtina L. Y., Belkina L. M. Effect of the alloxane diabetes on the cardio-vascular system function and lipid peroxidation in rats of different genetic strains // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2014. VOL. 58. № 1. PP. 37–43.
Issue
Vol. 58 No. 1 (2014)
Section
Original research