Features of the pharmacokinetics of ceftriaxone during the antiorthostatic hypokinesia in rats

  • M. V. Baranov Research Institute of Space Medicine of the Federal State Budgetary Institution of the Federal Research and Clinical Center of the Federal Medical and Biological Agency of Russia. 115682 Moscow, Orekhovy Boulevard, 28
  • E. N. Arkhipova Federal State Budgetary Institution "Research Institute of General Pathology and Pathophysiology" of the Russian Academy of Medical Sciences. 125315, Moscow, Baltic Street d.8
  • M. A. Lebedeva Federal State Budgetary Institution "Research Institute of General Pathology and Pathophysiology" of the Russian Academy of Medical Sciences. 125315, Moscow, Baltic Street d.8
  • N. N. Khlebnikova Federal State Budgetary Institution "Research Institute of General Pathology and Pathophysiology" of the Russian Academy of Medical Sciences. 125315, Moscow, Baltic Street d.8
  • Yu. S. Medvedeva Federal State Budgetary Institution "Research Institute of General Pathology and Pathophysiology" of the Russian Academy of Medical Sciences. 125315, Moscow, Baltic Street d.8
Keywords: microgravity, pharmacokinetic, ceftriaxone, rats

Abstract

This study was designed to investigate the effects of simulated microgravity on the plasma kinetics of ceftriaxone in rats. Comparative analysis of pharmacokinetic parameters in control and experimental groups has revealed the influence of antiorthostatic hypokinesia (ANOH) on the pharmacokinetics of ceftriaxone. Decreased level of maximum plasma concentration (Cmax) and bioavailability of ceftriaxone after single intramuscular (IM) injection were revealed in rats with antiorthostatic hypokinesia. The rate of absorption of the drug was higher respectively.

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Published
2014-02-03
How to Cite
Baranov M. V., Arkhipova E. N., Lebedeva M. A., Khlebnikova N. N., Medvedeva Y. S. Features of the pharmacokinetics of ceftriaxone during the antiorthostatic hypokinesia in rats // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2014. VOL. 58. № 1. PP. 28–31.
Issue
Vol. 58 No. 1 (2014)
Section
Original research