The influence of glutamate antibodies on the level of neurotransmitter monoamines in brain structures of rats with ischemic damage of prefrontal cortex

  • F. M. Shakova Federal State Budgetary Institution «Institution of General Pathology and pathophysiology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8
  • P. M. Klodt Federal State Budgetary Institution «Institution of Pharmacology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8
  • V. M. Kudrin Federal State Budgetary Institution «Institution of Pharmacology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8
  • T. V. Davydova Federal State Budgetary Institution «Institution of General Pathology and pathophysiology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8
  • G. A. Romanova Federal State Budgetary Institution «Institution of General Pathology and pathophysiology» of the Russion Academy of Medical Science, Russian Federation, 125315, Moscow, Baltiiskaya, 8
Keywords: rats, antibodies to glutamate, monoamines, serotonin, dopamine, prefrontal сortex of brain, hippocampus

Abstract

Experiments on the model of bilateral photothrombosis in prefrontal cortex showed that antibodies to glutamate one-time administered intranasally 1h after ischemic damage to the brain cortex lead to decrease of neurodegenerative influence of excitatory neurotransmitter after photothrombosis. It was showed the change of the level of dopamine, serotonin and their metabolites in hippocampus and prefrontal cortex.

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Published
2014-02-03
How to Cite
Shakova F. M., Klodt P. M., Kudrin V. M., Davydova T. V., Romanova G. A. The influence of glutamate antibodies on the level of neurotransmitter monoamines in brain structures of rats with ischemic damage of prefrontal cortex // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2014. VOL. 58. № 1. PP. 18–23.
Issue
Vol. 58 No. 1 (2014)
Section
Original research