Influence of transplantation of аuтоgenic меzenhymal stem cells from the fatty tissues on osseogenic process (experimental research)

  • A. A. Orlov Institute of general Pathology and Pathophysiology, RAMS, 8, Baltiyskaya str., 125315, Moscow, Russia
  • I. N. Saburina Institute of general Pathology and Pathophysiology, RAMS, 8, Baltiyskaya str., 125315, Moscow, Russia
  • S. D. Sisoev Institute of general Pathology and Pathophysiology, RAMS, 8, Baltiyskaya str., 125315, Moscow, Russia
  • A. D. Grigorian Institute of general Pathology and Pathophysiology, RAMS, 8, Baltiyskaya str., 125315, Moscow, Russia
Keywords: Autogenic mezenchymal cells from an adipose tissue, stimulation bone formation, osseo genesis, bone graft

Abstract

In experiments on 48 rats of line Wistar, divided at 2 groups (first — basic group and 2-d group — group of comparison) through the use of morphological method was researched influence of mesenchymal stem cells (MSC) inoculated in the arrear of autogenic bone graft from tibia fixed at the surface of the jaw. The animals of group of comparison didn’t get MSC. Time frames of watching: 21, 60, 120 and 180 days, 6 rats on the point of experiment in either of the two of the group. Data of this research had shown the intensification of bone formation process in the basic group of experiment under the action of the inoculation of autogenic MSC from adipose tissue, and as consequence of it, in eventual, merge of bone formations in a single entity.

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Published
2014-02-03
How to Cite
Orlov A. A., Saburina I. N., Sisoev S. D., Grigorian A. D. Influence of transplantation of аuтоgenic меzenhymal stem cells from the fatty tissues on osseogenic process (experimental research) // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2014. VOL. 58. № 1. PP. 3–7.
Section
Original research