Risk factors for cardiovascular diseases and development of prehypertension

  • Vladimir V. Sherstnev P.K. Anokhin Research Institute of Normal Physiology, Moscow, Russia
  • Marina A. Gruden P.K. Anokhin Research Institute of Normal Physiology, Moscow, Russia http://orcid.org/0000-0001-6066-8908
  • V. P. Karlina Health and Medical Unit #170 of the Federal Medical and Biological Agency
  • V. M. Ryzhov Health and Medical Unit #170 of the Federal Medical and Biological Agency
  • A. V. Kuznetsova N.M. Emanuel Institute of Biochemical Physics
  • Robert D. Sewell Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, CF10 3NB, UK http://orcid.org/0000-0003-1702-5100
  • O. V. Senko A.A. Dorodnitsyn Computing Center, RAS of the Federal Research Center «Informatics and Management» of the RAS
DOI: https://doi.org/10.25557/0031-2991.2018.03.37-43
Keywords: prehypertension, optimal blood pressure, risk factors for cardiovascular disease, dysregulation

Abstract

The aim of the study was to investigate the relationship between risk factors for cardiovascular disease and development of prehypertension. Methods. Comparative and correlation analyses of modifiable and non-modifiable risk factors for cardiovascular disease were performed in subjects aged 30—60 with «optimal» blood pressure (n = 63, BP <120/80 mm Hg) and prehypertension (n = 52, BP = 120—139 / 80—89 mm Hg). Results. The group with prehypertension compared with the «optimal» blood pressure group had significantly increased serum levels of low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol, sedentary/intellectual type of occupation, and significant combinations of risk factors. The risk factor combinations included an increased level of LDL cholesterol and a sedentary/intellectual occupation; increased serum levels of creatinine and triglycerides; hereditary burden of kidney disease and a sedentary/intellectual occupation; hereditary burden of diabetes mellitus and cardiac left ventricular hypotrophy. In subjects with prehypertension compared to subjects with «optimal» blood pressure, changes in correlations (correlation number, direction, and strength) between parameters of risk factors were documented. Conclusion. The features of interrelationships between risk factors for cardiovascular disease observed in prehypertension are considered a manifestation of early dysregulation pathology and disordered regulation of physiological systems, which maintain optimal blood pressure.

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Published
2018-10-05
How to Cite
Sherstnev V. V., Gruden M. A., Karlina V. P., Ryzhov V. M., Kuznetsova A. V., Sewell R. D., Senko O. V. Risk factors for cardiovascular diseases and development of prehypertension // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2018. VOL. 62. № 3. PP. 37–43.
Issue
Vol. 62 No. 3 (2018)
Section
Original research

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