Regulation of a heart rhythm in mouse with asymptomatic and symptomatic models of Parkinson’s disease

Abstract

Imbalance of the autonomic regulation of the heart occurs in asymptomatic the stage of Parkinson`s disease. In the beginning of the symptomatic stage increases dysfunction of the heart. Vegetative balance is shifting in the direction of increasing the sympathetic effects on the heart and reduce the parasympathetic. Heart disorders associated with Parkinson’s disease, increase the risk of life-threatening arrhythmias and sudden cardiac death not only at the early symptomatic the stage, but also in asymptomatic the stage of the disease.