The role of VEGF, HSP-70 and protein S-100B in the potentiation effect of the neuroprotective effect of hypercapnic hypoxia

  • A. G. Bespalov Altay State Medical University, Barnaul, Lenin st., 40; Scientific-Research Institute of Physiology and Fundamental Medicine / 630117, Novosibirsk, Timakov st., 4
  • P. P. Tregub Altay State Medical University, Barnaul, Lenin st., 40
  • V. P. Kulikov Altay State Medical University, Barnaul, Lenin st., 40; Scientific-Research Institute of Physiology and Fundamental Medicine / 630117, Novosibirsk, Timakov st., 4
  • A. I. Pijanzin Altay State Medical University, Barnaul, Lenin st., 40
  • A. A. Belousov Altay State Medical University, Barnaul, Lenin st., 40
Keywords: hypoxia, hypercapnia hypercapnic hypoxia, VEGF, HSP-70, S-100B, neuroprotection

Abstract

Studied the role of VEGF, HSP-70 and S-100B in potentiating hypercapnia neuroprotective effect of hypoxia. Demonstrated that neuroprotective effects when exposed hypercapnic hypoxia-mediated protein synthesis increased S-100B, mainly due to the action of carbon dioxide, and not oxygen deficiency . Neuroprotective effects of HSP-70 due to hypoxia , but the combined effect of hypoxia and hypercapnia gives a significant increase in the synthesis of HSP-70 in comparison with the isolated effect of hypoxia . Vascularization activated equally as hypoxia and hypercapnia , without adding significant effects in combination. This suggests dominant effect hypercapnia , hypoxia compared in neuroprotection mechanisms related to protein S-100B, but not the protein VEGF, hypercapnia and potentiate the neuroprotective efficacy of hypoxia-related protein HSP-70.

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Published
2014-06-12
How to Cite
Bespalov A. G., Tregub P. P., Kulikov V. P., Pijanzin A. I., Belousov A. A. The role of VEGF, HSP-70 and protein S-100B in the potentiation effect of the neuroprotective effect of hypercapnic hypoxia // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2014. VOL. 58. № 2. PP. 24–27.
Issue
Vol. 58 No. 2 (2014)
Section
Original research