Influence of the nitric oxide donors on the microcirculation in infusion therapy of the experimental hemorrhagic shock

Authors

  • M. I. Remizova Russian Research Institute of Hematology and Transfusiology, St-Petersburg, Russia
  • K. A. Gerbout Russian Research Institute of Hematology and Transfusiology, St-Petersburg, Russia
  • G. V. Grishina Russian Research Institute of Hematology and Transfusiology, St-Petersburg, Russia
  • K. N. Nagornaya Russian Research Institute of Hematology and Transfusiology, St-Petersburg, Russia

Keywords:

hemorrhagic shock, infusion therapy, rats, blood circulation, nitric oxide, L-Arginine, Oxacom

Abstract

Infusion of the nitric oxide donors L-Arginine (150 mg/kg bolus) and Oxacom (3,2 mM/ kg bolus) with saline solution has been shown improves cardiovascular and metabolic changes in animal model of hemorrhagic shock. As a result improves survival rats. These data made this effect clinically attractive.

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Published

05-12-2014

Issue

Vol. 58 No. 4 (2014)

Section

Original research

How to Cite

Remizova M.I., Gerbout K.A., Grishina G.V., Nagornaya K.N. Influence of the nitric oxide donors on the microcirculation in infusion therapy of the experimental hemorrhagic shock. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2014; 58(4): 91–95. Accessed June 24, 2026 https://pfiet.ru/article/view/904

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