Influence of the nitric oxide donors on the microcirculation in infusion therapy of the experimental hemorrhagic shock

Authors

  • M. I. Remizova Russian Research Institute of Hematology and Transfusiology, St-Petersburg, Russia
  • K. A. Gerbout Russian Research Institute of Hematology and Transfusiology, St-Petersburg, Russia
  • G. V. Grishina Russian Research Institute of Hematology and Transfusiology, St-Petersburg, Russia
  • K. N. Nagornaya Russian Research Institute of Hematology and Transfusiology, St-Petersburg, Russia

Keywords:

hemorrhagic shock, infusion therapy, rats, blood circulation, nitric oxide, L-Arginine, Oxacom

Abstract

Infusion of the nitric oxide donors L-Arginine (150 mg/kg bolus) and Oxacom (3,2 mM/ kg bolus) with saline solution has been shown improves cardiovascular and metabolic changes in animal model of hemorrhagic shock. As a result improves survival rats. These data made this effect clinically attractive.

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Published

05-12-2014

Issue

Vol. 58 No. 4 (2014)

Section

Original research

How to Cite

Remizova M. I. [et al.]. Influence of the nitric oxide donors on the microcirculation in infusion therapy of the experimental hemorrhagic shock // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2014. VOL. 58. № 4. PP. 91–95.

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