Taurine influence on heart mitochondrial bioenergy processes of rats with insulin resistance syndrome

Abstract

Taurine impact on heart mitochondria functional activity of rats with metabolic syndrome induced by high fructose diet was investigated. It has been established that taurine suppresses insulin resistance and carbohydrates intolerance, visceral fat accumulation and body mass gain increase. It was shown taurine application in animals with insulin resistance syndrome favours mitochondrial dysfunction decrease in heart due to normalization of ADF-stimulated respiration rate in the metabolic state 3 in NAD-depended substrates presence. Given results can indicate oxidative phosphorylation processes restoration at the complex I of heart mitochondrial electron transport chain under insulin resistance syndrome. Pharmacological properties of taurine that indicate its application advisability to cardiovascular pathology and metabolic syndrome prevention and treatment were detected.