Mutational burden of mitochondrial genome in different organs and tissues in human

Abstract

In the present article the literature data on studies of the heteroplasmy level of human mitochondrial genome in different organs (muscles, liver, kidneys, brain, heart, lungs, hair, small and large bowel, spleen) and tissues (buccal, leukocytes, ruinous epithelial cells) are analyzed. The difference in mutational burden levels of mitochondrial genome between samples of such organs and tissues is shown. Meanwhile, certain regularity was observed in heteroplasmy level distribution of mitochondrial mutations in these samples.