Hypoglycemic properties of pectine from pumpkin (Cucurbita maxima d.) in a model of alloxan-induced type 1 diabete mellitus

Authors

  • Tatyana В. Fedorova A.N. Bach Institute of Biochemistry, the Federal Research Center “Fundamentals of Biotechnology”, Russian Academy of Sciences, Leninsky Prosp. 33, Bldg 1, Moscow 119071, Russia http://orcid.org/0000-0002-0355-6800
  • А. А. Torkova A.N. Bach Institute of Biochemistry, the Federal Research Center “Fundamentals of Biotechnology”, Russian Academy of Sciences, Leninsky Prosp. 33, Bldg 1, Moscow 119071, Russia http://orcid.org/0000-0002-7671-8655
  • K. V. Lisitskaya A.N. Bach Institute of Biochemistry, the Federal Research Center “Fundamentals of Biotechnology”, Russian Academy of Sciences, Leninsky Prosp. 33, Bldg 1, Moscow 119071, Russia http://orcid.org/0000-0002-3922-5253
  • I. B. Alchinova Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow 125315, Russia http://orcid.org/0000-0001-5294-7317

DOI:

https://doi.org/10.25557/0031-2991.2018.02.82-89

Keywords:

alloxan-induced diabetes mellitus, cholesterol, pumpkin pectin, reactive oxygen species, fructosamine

Abstract

Hyperglycemia is a biochemically defined initial symptom of diabetes and its serious complications (atherosclerosis, retinopathy, kidney damage). Pectins are currently considered as novel plant-produced hypoglycemic agents. The aim of this study was to evaluate bio-functional properties of pumpkin pectin obtained from pumpkin pulp using cavitation-membrane technologies in a model of alloxan-induced diabetes. Methods. Male Wistar rats were used in the experiments. Diabetes was modeled by injections of 4.3% alloxan monohydrate solution. The development of diabetes was confirmed by glucose concentration in peripheral blood (glucose levels of >

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Published

01-06-2018

Issue

Vol. 62 No. 2 (2018)

Section

Original research

How to Cite

Fedorova T.В., Torkova А.А., Lisitskaya K.V., Alchinova I.B. Hypoglycemic properties of pectine from pumpkin (Cucurbita maxima d.) in a model of alloxan-induced type 1 diabete mellitus. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2018; 62(2): 82–89. https://doi.org/10.25557/0031-2991.2018.02.82-89

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