Метаболический синдром у женщин репродуктивного возраста: анализ «неинсулиновых» индексов инсулинорезистентности

Abstract

Abstract. The metabolic syndrome (MS) prevalence among reproductive age women at the Russian Federation reflects global trends and consist of 20-40%. Indirect (non-insulin) indices of insulin resistance (IR) are an important tool for assessing the risk of metabolic disorders without complex laboratory tests. The aim of this study was to analyze of indirect (non-insulin) indices of insulin resistance in women of reproductive age with metabolic syndrome. A total of 385 women of reproductive age (18-44 years) were examined. 92 women formed the control group (practically healthy women) and 293 - the group with MS. Clinical, instrumental, laboratory and statistical research methods were used. Anthropometric, biochemical and mixed indices were calculated. The results of the study showed statistically significantly higher values ​​of the following indicators: BFP (Body Fat Percentage) (p<0.0001), BAI (Body Adiposity Index) (p<0.0001), WC/height (p<0.0001), TYG (Triglyceride (TAG)-Glucose Index) (p<0.0001), TAG/HDL-C (p<0.0001), WTI (Waist-Triglyceride Index) (p<0.0001) and LAP (Lipid accumulation product) (p<0.0001) in the group of women with MS compared to the control group. The indicators with the highest specificity and sensitivity were: BFP (p<0.0001) and BAI (p<0.0001). Analysis of “non-insulin” indices of insulin resistance in reproductive age women with MS can serve as an additional criterion for the progression of metabolic disorders, as well as the severity of the pathological process.