Метаболизм гомоцистеина на экспериментальных моделях гипергомоцистеинемии у грызунов. Часть 1: генетические модели.

Александр Владимирович Иванов; Эдуард Даниэлевич Вирюс; Виталий Игоревич Логинов; Илия Сергеевна Зимина; Алексей Михайлович Бурденный; Валерий Васильевич Александрин; Аслан Амирханович Кубатиев

doi:10.25557/0031-2991.2020.04.118-124

Homocysteine metabolism in experimental models of hyperhomocysteinemia in rodents. Part 1: genetic models.

Authors

A.V. Ivanov Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia http://orcid.org/0000-0002-2424-6115
E.D. Virus Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia https://orcid.org/0000-0001-9371-6494
V.I. Loginov Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia https://orcid.org/0000-0003-2668-8096
I.S. Zimina Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia https://orcid.org/0000-0003-3304-4686
A.M. Burdennyy Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia https://orcid.org/0000-0002-9398-8075
V.V. Alexandrin Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia https://orcid.org/0000-0003-4625-6522
A.A. Kubatiev Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia; Russian Medical Academy of Continuous Professional Education, Barrikadnaya Str., 2/1, bld. 1, Moscow, 125993, Russia https://orcid.org/0000-0001-8077-2905

DOI:

https://doi.org/10.25557/0031-2991.2020.04.118-124

Keywords:

homocysteine, hyperhomocysteinemia, modeling, metabolism, methionine S-adenosylhomocysteine

Abstract

Modeling hyperhomocysteinemia in rodents is a common way to study the role of homocysteine in pathogenesis of various diseases (myocardial infarction, stroke, cognitive impairment, Alzheimer’s disease, kidney failure, etc.). This review focuses on biochemical aspects of homocysteine metabolism, genetic methods for modeling hyperhomocysteinemia in rats and mice, and effects of these models on metabolism of both homocysteine itself and related metabolites (methionine, cysteine, S-adenosylmethionine, S-adenosylhomocysteine).

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Author Biographies

A.V. Ivanov, Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia

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E.D. Virus, Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia

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V.I. Loginov, Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia

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I.S. Zimina, Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia

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A.M. Burdennyy, Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia

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V.V. Alexandrin, Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia

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A.A. Kubatiev, Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia; Russian Medical Academy of Continuous Professional Education, Barrikadnaya Str., 2/1, bld. 1, Moscow, 125993, Russia

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Published

26-11-2020

Issue

Vol. 64 No. 4 (2020)

Section

Reviews

How to Cite

Ivanov A. [et al.]. Homocysteine metabolism in experimental models of hyperhomocysteinemia in rodents. Part 1: genetic models. // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2020. VOL. 64. № 4. PP. 118–124.

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Homocysteine metabolism in experimental models of hyperhomocysteinemia in rodents. Part 1: genetic models.

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