Электрическая активность сердца и микроциркуляция крови в миокарде крыс в условиях острой алкогольной интоксикации

Irina Mikhailovna Roshchevskaya; Svetlana Leonidovna Smirnova; Sofya Alekseevna Simonenko; Vladimir Valerievich Barchukov; Joseph Borisovich Tsorin; Marina Borisovna Vititnova; Sergey Alexandrovich Kryzhanovsky

doi:10.48612/pfiet/0031-2991.2025.03.17-27

Irina Mikhailovna Roshchevskaya Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, 8 Baltijskaya St., Moscow, 125315, Russian Federation https://orcid.org/0000-0002-6108-1444
Svetlana Leonidovna Smirnova Federal Research Center Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences, 24 Kommunisticheskaya St., Syktyvkar, 167982, Russian Federation https://orcid.org/0000-0003-4292-2444
Sofya Alekseevna Simonenko Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, 8 Baltijskaya St., Moscow, 125315, Russian Federation
Vladimir Valerievich Barchukov Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, 8 Baltijskaya St., Moscow, 125315, Russian Federation https://orcid.org/0000-0003-4229-3107
Joseph Borisovich Tsorin Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, 8 Baltijskaya St., Moscow, 125315, Russian Federation https://orcid.org/0000-0002-3988-7724
Marina Borisovna Vititnova Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, 8 Baltijskaya St., Moscow, 125315, Russian Federation https://orcid.org/0000-0002-7407-7516
Sergey Alexandrovich Kryzhanovsky Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, 8 Baltijskaya St., Moscow, 125315, Russian Federation https://orcid.org/0000-0003-2832-4739

DOI: https://doi.org/10.48612/pfiet/0031-2991.2025.03.17-27

Keywords: acute alcohol intoxication, electrical activity of the heart, blood microcirculation, arrhythmia

Abstract

Purpose of the study. Study of the heart electrical activity and the blood microcirculation in the myocardium of rats under conditions of acute alcohol intoxication (AAI).

Materials and methods. The studies were conducted on white outbred male rats. Modeling of AAI was carried out with intraperitoneal injection of 25% ethanol solution (5 g/kg). The measurement of microcirculation was carried out using a computerized laser analyzer “Lazma-OP2” (production of SPF Lazma, Russia) using the LDF 3.0.2.395 program. To evaluate the EAH in the II bipolar lead from the limbs, the duration (in ms) was analyzed: R-R interval; P spike; segment and interval PQ; complex QRS; interval from the peak R to point j; intervals J-T_pik and T_pik-T_end; Qt interval. The duration of the сorrigated QT interval according to the Basette and heart rate was calculated. The amplitude of the P, R and S, T-waves (in mV) was measured. The measurements were carried out in the initial state, two days later at the AAI, a day after the abolition of ethyl alcohol.

Results. In the AAI, a significant reduction in the duration of the P-wave, QRS complex due to the ascending part of the R-wave, the J-T_pic interval, the QT interval and QT_C were revealed. A day after the ethanol deprivation the duration of the P-wave, the QRS complex is restored to the initial value, the intervals of J-T_pic and T_pic-T_end, QT and QT_c are increasing significantly more than the initial state. Unlike heart electrical activity, the blood microcirculation in the myocardium of rats against the background of the AAI did not change.

Conclusion. The results indicate a high risk of heart rhythm disturbances in an AAI. Violations of the myocardium electrical stability in the AAI, apparently, are associated with the direct toxic effect of ethanol on the heart muscle.

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Electrical activity of the heart, and blood microcirculation in the myocardium of rats under conditions of acute alcohol intoxication

Abstract

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