The state of the oxidant-antioxidant system in acute gestational pyelonephritis at different trimesters of pregnancy
Keywords:
gestational pyelonephritis, disturbance of the parameters of the oxidant-antioxidant system
Abstract
Abstract.
Introduction. In the pathogenesis of many diseases of pregnant women, a significant role is given to the systemic inflammatory response and oxidative stress, due to the imbalance between prooxidants and the antioxidant defense system. Currently, acute pyelonephritis during pregnancy is one of the most common diseases of the urinary system. In the literature, there are practically no data on the study of the state of the pro- and antioxidant system in acute pyelonephritis in dynamics in each trimester of pregnancy.
Objective of the study: study of the state of the pro- and antioxidant system at the systemic and local level in acute serous pyelonephritis in different trimesters of gestation.
Material and methods. The study included 130 women (mean age 25.1±4.3 years), divided into groups: comparison (20 healthy women), (20 patients with a verified diagnosis of acute serous pyelonephritis), (15 women in the 1st, 2nd and 3rd trimesters of gestation); main groups (15 women in each) with acute pyelonephritis in the 1st, 2nd and 3rd trimesters of pregnancy. The oxidant-antioxidant system parameters in plasma and erythrocytes of peripheral blood and urine were studied.
Results. In acute pyelonephritis in all trimesters of gestation, to a greater extent in the second and third, the development of systemic inflammation, oxidative stress and endothelial dysfunction has been established, since at the systemic (peripheral blood plasma) and local (erythrocytes and urine) level, the content of malondialdehyde, acyl hydroperoxides, neopterin, C-reactive protein, stable metabolites of nitric oxide is increased, antioxidant defense factors and endothelin-1 levels are reduced.
Downloads
Download data is not yet available.
References
1. Neimark A.I., Kapsargin F.P., Sindeeva L.V., Dugarzhapova T.O., Firsov M.A. Clinical and anthropometric parallels in the diagnosis of pyelonephritis in pregnant women. Urologicheskie vedomosti. 2022; 12(1): 21-32. https://doi.org/10.17816/uroved101478 (in Russian)
2. Shulzhenko E.V. Pregnancy, childbirth and the postpartum period in women with kidney diseases. Study guide. [Beremennost', rody i poslerodovyj period u zhenshhin s zabolevanijami pochek. Uchebnoe posobie]. Blagoveshchensk: 2019 (in Russian)
3. Zhambalova B.A., Nosikova I.N., Malushenko S.V., Maksina A.G., Gankovskaya L.V., Dobrokhotova Yu.E., Osipov A.N., Tesyolkin Yu.O. Oxidative stress indicators in healthy pregnant women and pregnant women with urogenital infection in early gestation. Akusherstvo i ginekologija. 2017; 9: 40-46. https://doi.org/10.18565/aig.2017.9.40-6 (in Russian)
4. Efremova O.A., Kamyshnikova L.A., Veysalov S.E., Sviridova M.S., Kiselevich M.M. The state of the oxidative stress - antioxidant defense system in patients with chronic pyelonephritis. Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta. Serija: Medicina. Farmacija. 2019; 42(2): 158-166. https://doi.org/10.18413/2075-4728-2019-42-2-158-166 (in Russian)
5. Graf A.V., Baizhumanov A.A., Maslova M.V., Krushinskaya Ya.V., Maklakova A.S., Sokolova N.A., Kamensky A.A. Activity of the antioxidant system during pregnancy under normal conditions and under hypoxia. Vestnik Moskovskogo universiteta. Serija 16: Biologija. 2021; 76(3): 126-133 (in Russian)
6. Minasyan A.M., Khripunova G.I., Shlyakhova I.Yu. Activity of lipid peroxidation and antioxidant defense system in pregnant women with chronic pyelonephritis in the remission phase complicated by preeclampsia. Mezhdunarodnyj zhurnal jeksperimental'nogo obrazovanija. 2015; 2(1): 40-41 (in Russian)
7. Zaloznyaya I.V., Kopteeva E.V., Milyutina Yu.P., Korenevsky A.V., Arutyunyan A.V., Shelaeva E.V., Kapustin R.V., Kogan I.Yu. Evaluation of the content of oxidative stress markers in the maternal and umbilical cord blood of pregnant women with diabetes mellitus in terms of blood flow redistribution in the venous system of the fetus. Akusherstvo i ginekologija. 2024; 10: 41-51. https://doi.org/10.18565/aig.2024.178 (in Russian)
8. Spiridonova E.V. Prognostic value of assessing lipid peroxidation indices, antioxidant activity of amniotic fluid in the development of pregnancy complications of placental genesis. Mat' i ditja v Kuzbasse. 2015; 2(61): 82-86 (in Russian)
9. Bakhareva I.V. The role of antioxidants in high-risk pregnancy. Ginekologija. 2014; 16(1): 90-96 (in Russian)
10. Khodjaeva M.Yu., Abduakhadov A. Free radicals and their role in the occurrence of oxidative stress. Internauka. 2023; 36-1(306): 31-34. https://doi.org/10.29188/2222-8543-2021-14-2-14-22 (in Russian)
11. Denisyukova A.S., Pavlyuchenko I.I., Ivanova L.A., Popov Z.S., Popov V.I. Features of changes in the antioxidant/prooxidant system in patients with type 1 and type 2 diabetes mellitus complicated by distal neuropathy and diabetic foot syndrome. RMZh. 2023; 2: 3-6 (in Russian)
12. Pavlyuchenko I.I., Bezrukova O.S., Zobenko V.Ya., Esauenko E.E., Basov A.A., Storozhuk A.P. The state of the antioxidant defense system and the cytokine profile of the blood at different stages of physiologically proceeding pregnancy. Krymskij zhurnal jeksperimental'noj i klinicheskoj mediciny. 2020; 10(2): 40-47. https://doi.org/10.37279/2224-6444-2020-10-2-40-47 (in Russian)
13. Pestryaeva L.A., Malgina G.B., Smirnova E.E., Tretyakova T.B., Dankova I.V., Borisova S.V. Antioxidant status of blood in women of advanced reproductive age during induced pregnancy. Problemy reprodukcii. 2020; 26(1): 13-17. https://doi.org/10.17116/repro20202601113 (in Russian)
14. Bogolepova A.N. The role of oxidative stress in the development of vascular cognitive disorders. Zhurnal nevrologii i psihiatrii im. C.C. Korsakova. 2020; 120(8): 133-139. https://doi.org/10.17116/jnevro2020120081133 (in Russian)
15. Fedorova N.D., Sumbatyan D.A., Sokolov A.V., Filatov M.V., Trashkov A.P., Varfolomeeva E.Yu. The influence of acute phase proteins of inflammation on the activity of peripheral blood neutrophils. Biofizika. 2023; 68(3): 522-528. https://doi.org/10.31857/S0006302923030146 (in Russian)
16. Zamorsky I.I., Unguryan T.N., Melnichuk S.P., Zamorsky I.I. Antioxidant activity of ceruloplasmin under conditions of rhabdomyolysis-induced acute kidney injury. Biofizika. 2019; 64(6): 1221-1224. https://doi.org/10.1134/S000630291905022X (in Russian)
17. Parshevnikova A.S. Active forms of oxygen and ways of their neutralization in the body. Bjulleten' Severnogo gosudarstvennogo medicinskogo universiteta. 2022; 1(47): 55-57 (in Russian)
18. Shestakova M.A., Proskurnina E.V., Shcherbakova L.N., Panina O.B., Granulosa cells as sources of reactive oxygen species. Akusherstvo i ginekologija. 2019; 1: 42-49. https://doi.org/10.18565/aig.2019.1.42-49 (in Russian)
19. Galimova S.Sh., Abdrakhmanova N.I., Sebyakina ID, Galimov Sh.N., Mochalov K.S., Galimov K.Sh., Fedorovtseva Zh.G., Sadykova A.R., Galimova E.F., Litvitsky P.F. Thrombocytopenia and C-reactive protein as markers of hemorrhagic fever with renal syndrome complicated by acute renal failure. Vestnik sovremennoj klinicheskoj mediciny. 2024; 17(6): 13-18. https://doi.org/10.20969/VSKM.2024.17(6).13-18 (in Russian)
20. Utkina E.A., Afanasyeva O.I., Pokrovsky S.N. C-reactive protein: pathogenetic properties and possible therapeutic target. Rossijskij kardiologicheskij zhurnal. 2021; 26(6): 128-134. https://doi.org/10.15829/1560-4071-2021-4138 (in Russian)
21. Eleukina A.A., Korzhumbaev A.N., Akshalov A.R., Kapezov K.E., Abdikhalilov U.N. Changes in C-reactive protein in blood serum in coronavirus and bacterial pneumonia. Tendencii razvitija nauki i obrazovanija. 2021; 74(1): 43-48. https://doi.org/10.18411/lj-06-2021-09 (in Russian)
22. Galimova S.Sh., Litvitsky P.F., Galimova E.F., Mochalov K.S., Galimov Sh.N. Molecular aspects of the pathogenesis of hemorrhagic fever with renal syndrome. Patologicheskaja fiziologija i jeksperimental'naja terapija. 2023; 67(2): 106-111. https://doi.org/10.25557/0031-2991.2023.02.106-111 (in Russian)
23. Aliyeva A.M., Pinchuk T.V., Voronkova K.V., Shnahova L.M., Ettinger O.A., Akhmedova M.F., Valiev R.K., Kalova M.R., Gasanova E.T., Nikitin I.G. Neopterin as a biomarker of chronic heart failure (review of current literature). Consilium Medicum. 2021; 23(10): 756-759. https://doi.org/10.26442/20751753.2021.10.201113 (in Russian)
24. Katkova N.Yu., Bodrikova O.I., Sergeeva A.V., Andosova L.D., Shahova K.A., Bezrukova I.M., Pokusaeva K.B., Ryzhova N.K. Local immune status, neopterin and cortisol content in different variants of preterm labor. Zhurnal akusherstva i zhenskih boleznej. 2017; 66(3): 60-70. https://doi.org/10.17816/JOWD66360-70 (in Russian)
25. Levkovich M.A., Krukier I.I., Erdzhanyan L.L., Kalinina A.V. The importance of inflammatory mediators in the pathogenesis of premature birth. Rossijskij immunologicheskij zhurnal. 2019;13(2-1(22)): 365-367. https://doi.org/10.31857/S102872210006629-6 (in Russian)
26. Dorofienko N.N. The role of vascular endothelium in the body and universal mechanisms of changing its activity (literature review). Bjulleten' fiziologii i patologii dyhanija. 2018; 68: 107-116. https://doi.org/10.12737/article_5b1a0351210298.18315210 (in Russian)
27. Grebenchikov O.A., Dolgikh V.T., Prokofiev M.D. Endothelial dysfunction as the most important pathogenetic factor in the development of critical condition. Vestnik SurGU. Medicina. 2021; 3(49): 51-60. https://doi.org/10.34822/2304-9448-2021-3-51-60 (in Russian)
28. Ivanov A.N., Popykhova E.B., Tereshkina N.E., Stepanova T.V., Zlobina O.V., Norkin I.A. Vasomotor function of the endothelium. Uspehi fiziologicheskih nauk. 2020; 51(4): 82-104. https://doi.org/10.31857/S0301179820030066 (in Russian)
29. Drukker N.A., Selyutina S.N., Ermolova N.V., Chikin A.L., Palieva N.V. The importance of nitric oxide and cachectin in the pathogenesis of premature birth. Akusherstvo i ginekologija. 2020; 3: 72-78. https://doi.org/10.18565/aig.2020.3.72-78 (in Russian)
30. Prokopenko E.I., Nikolskaya I.G., Vatazin A.V., Vetchinnikova O.N. Chronic kidney disease and pregnancy. Monograph. [Hronicheskaja bolezn' pochek i beremennost'. Monografija]. Мoscow: Publishing house OOO "Buki Vedi"; 2018 (in Russian)
2. Shulzhenko E.V. Pregnancy, childbirth and the postpartum period in women with kidney diseases. Study guide. [Beremennost', rody i poslerodovyj period u zhenshhin s zabolevanijami pochek. Uchebnoe posobie]. Blagoveshchensk: 2019 (in Russian)
3. Zhambalova B.A., Nosikova I.N., Malushenko S.V., Maksina A.G., Gankovskaya L.V., Dobrokhotova Yu.E., Osipov A.N., Tesyolkin Yu.O. Oxidative stress indicators in healthy pregnant women and pregnant women with urogenital infection in early gestation. Akusherstvo i ginekologija. 2017; 9: 40-46. https://doi.org/10.18565/aig.2017.9.40-6 (in Russian)
4. Efremova O.A., Kamyshnikova L.A., Veysalov S.E., Sviridova M.S., Kiselevich M.M. The state of the oxidative stress - antioxidant defense system in patients with chronic pyelonephritis. Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta. Serija: Medicina. Farmacija. 2019; 42(2): 158-166. https://doi.org/10.18413/2075-4728-2019-42-2-158-166 (in Russian)
5. Graf A.V., Baizhumanov A.A., Maslova M.V., Krushinskaya Ya.V., Maklakova A.S., Sokolova N.A., Kamensky A.A. Activity of the antioxidant system during pregnancy under normal conditions and under hypoxia. Vestnik Moskovskogo universiteta. Serija 16: Biologija. 2021; 76(3): 126-133 (in Russian)
6. Minasyan A.M., Khripunova G.I., Shlyakhova I.Yu. Activity of lipid peroxidation and antioxidant defense system in pregnant women with chronic pyelonephritis in the remission phase complicated by preeclampsia. Mezhdunarodnyj zhurnal jeksperimental'nogo obrazovanija. 2015; 2(1): 40-41 (in Russian)
7. Zaloznyaya I.V., Kopteeva E.V., Milyutina Yu.P., Korenevsky A.V., Arutyunyan A.V., Shelaeva E.V., Kapustin R.V., Kogan I.Yu. Evaluation of the content of oxidative stress markers in the maternal and umbilical cord blood of pregnant women with diabetes mellitus in terms of blood flow redistribution in the venous system of the fetus. Akusherstvo i ginekologija. 2024; 10: 41-51. https://doi.org/10.18565/aig.2024.178 (in Russian)
8. Spiridonova E.V. Prognostic value of assessing lipid peroxidation indices, antioxidant activity of amniotic fluid in the development of pregnancy complications of placental genesis. Mat' i ditja v Kuzbasse. 2015; 2(61): 82-86 (in Russian)
9. Bakhareva I.V. The role of antioxidants in high-risk pregnancy. Ginekologija. 2014; 16(1): 90-96 (in Russian)
10. Khodjaeva M.Yu., Abduakhadov A. Free radicals and their role in the occurrence of oxidative stress. Internauka. 2023; 36-1(306): 31-34. https://doi.org/10.29188/2222-8543-2021-14-2-14-22 (in Russian)
11. Denisyukova A.S., Pavlyuchenko I.I., Ivanova L.A., Popov Z.S., Popov V.I. Features of changes in the antioxidant/prooxidant system in patients with type 1 and type 2 diabetes mellitus complicated by distal neuropathy and diabetic foot syndrome. RMZh. 2023; 2: 3-6 (in Russian)
12. Pavlyuchenko I.I., Bezrukova O.S., Zobenko V.Ya., Esauenko E.E., Basov A.A., Storozhuk A.P. The state of the antioxidant defense system and the cytokine profile of the blood at different stages of physiologically proceeding pregnancy. Krymskij zhurnal jeksperimental'noj i klinicheskoj mediciny. 2020; 10(2): 40-47. https://doi.org/10.37279/2224-6444-2020-10-2-40-47 (in Russian)
13. Pestryaeva L.A., Malgina G.B., Smirnova E.E., Tretyakova T.B., Dankova I.V., Borisova S.V. Antioxidant status of blood in women of advanced reproductive age during induced pregnancy. Problemy reprodukcii. 2020; 26(1): 13-17. https://doi.org/10.17116/repro20202601113 (in Russian)
14. Bogolepova A.N. The role of oxidative stress in the development of vascular cognitive disorders. Zhurnal nevrologii i psihiatrii im. C.C. Korsakova. 2020; 120(8): 133-139. https://doi.org/10.17116/jnevro2020120081133 (in Russian)
15. Fedorova N.D., Sumbatyan D.A., Sokolov A.V., Filatov M.V., Trashkov A.P., Varfolomeeva E.Yu. The influence of acute phase proteins of inflammation on the activity of peripheral blood neutrophils. Biofizika. 2023; 68(3): 522-528. https://doi.org/10.31857/S0006302923030146 (in Russian)
16. Zamorsky I.I., Unguryan T.N., Melnichuk S.P., Zamorsky I.I. Antioxidant activity of ceruloplasmin under conditions of rhabdomyolysis-induced acute kidney injury. Biofizika. 2019; 64(6): 1221-1224. https://doi.org/10.1134/S000630291905022X (in Russian)
17. Parshevnikova A.S. Active forms of oxygen and ways of their neutralization in the body. Bjulleten' Severnogo gosudarstvennogo medicinskogo universiteta. 2022; 1(47): 55-57 (in Russian)
18. Shestakova M.A., Proskurnina E.V., Shcherbakova L.N., Panina O.B., Granulosa cells as sources of reactive oxygen species. Akusherstvo i ginekologija. 2019; 1: 42-49. https://doi.org/10.18565/aig.2019.1.42-49 (in Russian)
19. Galimova S.Sh., Abdrakhmanova N.I., Sebyakina ID, Galimov Sh.N., Mochalov K.S., Galimov K.Sh., Fedorovtseva Zh.G., Sadykova A.R., Galimova E.F., Litvitsky P.F. Thrombocytopenia and C-reactive protein as markers of hemorrhagic fever with renal syndrome complicated by acute renal failure. Vestnik sovremennoj klinicheskoj mediciny. 2024; 17(6): 13-18. https://doi.org/10.20969/VSKM.2024.17(6).13-18 (in Russian)
20. Utkina E.A., Afanasyeva O.I., Pokrovsky S.N. C-reactive protein: pathogenetic properties and possible therapeutic target. Rossijskij kardiologicheskij zhurnal. 2021; 26(6): 128-134. https://doi.org/10.15829/1560-4071-2021-4138 (in Russian)
21. Eleukina A.A., Korzhumbaev A.N., Akshalov A.R., Kapezov K.E., Abdikhalilov U.N. Changes in C-reactive protein in blood serum in coronavirus and bacterial pneumonia. Tendencii razvitija nauki i obrazovanija. 2021; 74(1): 43-48. https://doi.org/10.18411/lj-06-2021-09 (in Russian)
22. Galimova S.Sh., Litvitsky P.F., Galimova E.F., Mochalov K.S., Galimov Sh.N. Molecular aspects of the pathogenesis of hemorrhagic fever with renal syndrome. Patologicheskaja fiziologija i jeksperimental'naja terapija. 2023; 67(2): 106-111. https://doi.org/10.25557/0031-2991.2023.02.106-111 (in Russian)
23. Aliyeva A.M., Pinchuk T.V., Voronkova K.V., Shnahova L.M., Ettinger O.A., Akhmedova M.F., Valiev R.K., Kalova M.R., Gasanova E.T., Nikitin I.G. Neopterin as a biomarker of chronic heart failure (review of current literature). Consilium Medicum. 2021; 23(10): 756-759. https://doi.org/10.26442/20751753.2021.10.201113 (in Russian)
24. Katkova N.Yu., Bodrikova O.I., Sergeeva A.V., Andosova L.D., Shahova K.A., Bezrukova I.M., Pokusaeva K.B., Ryzhova N.K. Local immune status, neopterin and cortisol content in different variants of preterm labor. Zhurnal akusherstva i zhenskih boleznej. 2017; 66(3): 60-70. https://doi.org/10.17816/JOWD66360-70 (in Russian)
25. Levkovich M.A., Krukier I.I., Erdzhanyan L.L., Kalinina A.V. The importance of inflammatory mediators in the pathogenesis of premature birth. Rossijskij immunologicheskij zhurnal. 2019;13(2-1(22)): 365-367. https://doi.org/10.31857/S102872210006629-6 (in Russian)
26. Dorofienko N.N. The role of vascular endothelium in the body and universal mechanisms of changing its activity (literature review). Bjulleten' fiziologii i patologii dyhanija. 2018; 68: 107-116. https://doi.org/10.12737/article_5b1a0351210298.18315210 (in Russian)
27. Grebenchikov O.A., Dolgikh V.T., Prokofiev M.D. Endothelial dysfunction as the most important pathogenetic factor in the development of critical condition. Vestnik SurGU. Medicina. 2021; 3(49): 51-60. https://doi.org/10.34822/2304-9448-2021-3-51-60 (in Russian)
28. Ivanov A.N., Popykhova E.B., Tereshkina N.E., Stepanova T.V., Zlobina O.V., Norkin I.A. Vasomotor function of the endothelium. Uspehi fiziologicheskih nauk. 2020; 51(4): 82-104. https://doi.org/10.31857/S0301179820030066 (in Russian)
29. Drukker N.A., Selyutina S.N., Ermolova N.V., Chikin A.L., Palieva N.V. The importance of nitric oxide and cachectin in the pathogenesis of premature birth. Akusherstvo i ginekologija. 2020; 3: 72-78. https://doi.org/10.18565/aig.2020.3.72-78 (in Russian)
30. Prokopenko E.I., Nikolskaya I.G., Vatazin A.V., Vetchinnikova O.N. Chronic kidney disease and pregnancy. Monograph. [Hronicheskaja bolezn' pochek i beremennost'. Monografija]. Мoscow: Publishing house OOO "Buki Vedi"; 2018 (in Russian)
Published
16-12-2025
How to Cite
Holimenko I. M., Shatokhin M. N., Cannabis N. A., Kravtsov A. Y. The state of the oxidant-antioxidant system in acute gestational pyelonephritis at different trimesters of pregnancy // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2025. VOL. 69. № 4. PP. 111–122.
Issue
Section
Original research
