Relationships between blood cells, sex hormones, and lipid peroxidation in women with essential hypertension

Abstract

Close correlations exist between different blood cells (BC), blood pressure, heart function, results of hemodynamics tests, thrombodynamics, and blood coagulation in women with hypertension. Aim. The study addressed the role of different BCs and their combinations in regulation of estrogen, progesterone, prolactin, TBAreactive substances (TBARS), and antioxidant activity (AOA) in hypertensive patients. Methods. The study included 12 healthy women (control) and 72 patients with essential hypertension (EH). Patients with EH were divided into two groups; the first group (EH-1) consisted of 37 women with stage II EH receiving an antihypertensive therapy and the second group (EH-2) consisted of 35 women who, in addition to the drug therapy, yearly underwent 3-4 courses of kinesitherapy for 2-3 year on a regular basis. Results. Both in healthy women and patients of the EH-1 and EH-2 groups, the studied relationships were either positive or negative. In healthy women, LYM positively correlated with progesterone and inversely correlated with prolactin, and the NEU/BAS ratio positively correlated with progesterone. In patients of the EH-1 group, there were positive correlations of RBC with progesterone; EOS with prolactin; and LYM/EOS with estradiol; and NEU/MON, NEU/BAS, and LYM/BAS with progesterone. The NEU/LYM and NEU/EOS ratios inversely correlated with prolactin. In patients of the EH-2 group, there were positive correlations of WBC, NEU, and EOS with prolactin and inverse correlations of the RBC/WBC ratio with prolactin. Evaluation of correlations between blood indexes and the oxidant/antioxidant system showed that in healthy women, there were positive correlations of the MON count with TBARS and AOA; EOS with AOA; and the WBC/PLT ratio with TBARS. Patients of the EH-1 group showed a negative correlation of the total RBC count with AOA. Conclusion. In both healthy subjects and EH groups, almost all BCs and their relationships play a significant role in regulation of estradiol, progesterone, prolactin, and the lipid peroxidation/AOA system.