The role of autonomic dysfunction in pathogenesis of irritable bowel syndrome

  • M. A. Lebedeva The Institute of General Pathology and Pathophysiology RAMS, Russia, 125315, Moscow, Baltiyskaya str., 8
  • M. Yu. Karganov The Institute of General Pathology and Pathophysiology RAMS, Russia, 125315, Moscow, Baltiyskaya str., 8
  • Y. A. Kozlova Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare, Department, Russia, 115419, Moscow, Donskaya st., 43
  • G. N. Gotovtceva Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare, Department, Russia, 115419, Moscow, Donskaya st., 43
  • D. A. Tumurov Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare, Department, Russia, 115419, Moscow, Donskaya st., 43
  • A. A. Gudkova Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare, Department, Russia, 115419, Moscow, Donskaya st., 43
  • A. B. Guekht Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare, Department, Russia, 115419, Moscow, Donskaya st., 43
Keywords: irritable bowel syndrome, autonomic nervous system, skin sympathetic response, heart rate variability

Abstract

This article presents the results of a comparative study of autonomic disorders in patients with different types of irritable bowel syndrome (IBS). We used several clinical and instrumental methods, including the Veyn questionnaire, Kerdo autonomic index, skin sympathetic response and heart rate variability analysis. The results show a prevalence of sympathetic tone in all groups of patients (more pronounced in IBS with constipation), as well as an elevated stress index and decreased arterial baroreflex sensitivity. In the IBS with diarrhea group there was a reliable increase of power spectral density atvery low frequency and a lowered respiratory sinus arrhythmia.

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Published
2014-09-12
How to Cite
Lebedeva M. A., Karganov M. Y., Kozlova Y. A., Gotovtceva G. N., Tumurov D. A., Gudkova A. A., Guekht A. B. The role of autonomic dysfunction in pathogenesis of irritable bowel syndrome // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2014. VOL. 58. № 3. PP. 37–44.
Issue
Vol. 58 No. 3 (2014)
Section
Original research