Method for determining distinctive functional properties of neutrophils affecting bone metabolism in personal observations

Abstract

Background. In recent years, the potential involvement of various leukocyte subpopulations in bone metabolism has been demonstrated. One such subpopulation capable of influencing bone metabolism is neutrophils. However, determining the distinctive functional properties of these leukocytes in individual observations requires specialized, complex methods unavailable to conventional medical and preventive care facilities.

Methods. Based on an analysis of laboratory parameters of water and electrolyte balance, clinical blood tests, and bone turnover markers in 82 inpatients, using expert analytical technology, observations were identified that demonstrated a strong correlation between the deformation patterns of ratio panels and an increase in leukocyte count and activity.

Results.  It was shown that the "deformation" of water and electrolyte balance panels and clinical blood tests, coupled with the increasing influence of neutrophils on bone metabolism parameters, can differ and correspond to both osteosynthesis and osteolysis. The ability to detect such differences is supported by literature. Moreover, according to the authors, the method allows for the determination of high functional activity of neutrophils accumulating in tissues, including with "normal" white blood cell counts in a clinical blood test.

Conclusion. The results obtained substantiate the potential of using the described method as an auxiliary tool for assessing the impact of neutrophils on bone metabolism without the need for complex techniques based on individual values ​​of routine laboratory parameters in any linear healthcare facility.