Применение флавоноидов в экспериментальной терапии ревматоидного артрита
Ключевые слова:
Ревматоидный артрит, флавоноиды, механизм действия, перспективность клинического применения.
Аннотация
Обзор касается возможности потенциального применения флавоноидов в комплексном лечении ревматоидного артрита (РА). Анализируются многообещающие свойства флавонолов, флавонов, флаванонов, флаван-3-олов и изофлавонов, включающие противовоспалительный, антиоксидантный, антипролиферативный, иммуномодулирующий эффекты при отсутствии выраженной токсичности. Рассматриваются сведения, которые базируются на многочисленных экспериментальных данных, полученных в исследованиях in vitro и при использовании моделей, адекватно воспроизводящих РА у грызунов. В основе противоартритного действия флавоноидов лежит способность подавлять функциональную активность иммунных клеток, их рекрутирование в очаг воспаления синовиальной оболочки с ингибированием высвобождения и активации провоспалительных цитокинов и других факторов воспаления вследствие воздействия на соответствующие транскрипционные факторы и пути внутриклеточного сигнализирования. Антиоксидантное действие, как и ингибирование флавоноидами активности Т- и В-лимфоцитов вносят существенный вклад в развитие процесса иммунного воспаления. Важную положительную роль играет угнетение при РА гиперактивности фибробластоподобных синовиоцитов и активация их апоптоза, что ослабляет инвазивность патологического процесса и формирование паннуса. Имеет значение и ингибирование активности матриксных металлопротеиназ, обеспечивающих процесс костной резорбции при РА. Многообещающие экспериментальные данные получены при комбинировании флавоноидов с классическими противоартритными препаратами, такими как метотрексат. Наибольшее внимание в настоящее время уделяется противоартритной эффективности флавонола кверцетина.
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Литература
ЛИТЕРАТУРА
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Опубликован
27-10-2025
Как цитировать
Зверев Я. Ф., Рыкунова А. Я. Применение флавоноидов в экспериментальной терапии ревматоидного артрита // Патологическая физиология и экспериментальная терапия. 2025. Т. 69. № 4. С. 182–195.
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