Biological significance of the presence of lymphocytes in semen. A hypothesis.

Abstract

The article proposes a solution to a still unclear problem of the so-called "immune paradox of pregnancy" and the nature of tolerance to a semi-allogeneic fetus. A comprehensive analysis of a wide range of functional effects that we have identified in various studies of the inductive, therapeutic and prophylactic action of exogenous total RNA of lymphoid cells from healthy individuals in vivo, as well as the ability of total RNA of morphogenetic γδ-T-lymphocytes to reprogram and normalize pathological processes, has allowed us to reveal and clarify the true strategy of the effects of sperm components during fertilization. Thus, the obtained speculative picture appeared an exceptionally clear demonstration of the organization principle of evolving systems formulated in 1965 by V.A. Geodakyan. The principle is the asynchronous evolution of binary-conjugated subsystems, and it also harmoniously agrees with the unique observations and an exceptionally bold conclusion of A.A. Maksimov (1909) that "in the body of mammals there is one type of cells, lymphocytes ... which, depending on the diversity of their living conditions in the body of the embryo, look different and can produce different cells, products of differentiation." Finally, the concept proposed here allows answering the question of the origin of T-lymphocyte precursors in the embryogenesis of the thymus, which has not yet been resolved.