Hemoreological parameters in spontaneously hypertensive rats during the stages of increasing and stable blood pressure

Abstract

The purpose was to study hemorheological parameters and their correlations with the blood pressure (BP) in SHRs at the periods of increasing and stable high BP as compared to normotensive rats WKY. Methods. The experiments were carried out on 30 Wistar-Kyoto (WKY) and 40 spontaneously hypertensive rats (SHRs). During (7—8 week) and after (16—17 week) the increasing of the blood pressure, hemorheological parameters (blood and plasma viscosity, hematocrit, plasma fibrinogen concentration, RBC aggregation and deformability) were measured in SHRs and were compared to normotensive rats. Results. It was shown that during the increasing of the blood pressure (7—8 week) SHRs have increased blood viscosity due to the high hematocrit values. At the stable stages (16—17 week) SHRs also have increased blood viscosity and high hematocrit values, but moreover RBC hyperaggregation was observed. Conclusion. Enhancement of RBC aggregation in SHR rats with no difference in fibrinogen rats supposes that it may be the result of changes in the structure of erythrocyte membranes. Analysis of the dynamics and the correlation relationships between hemorheological parameters and blood pressure in SHRs shows the magnitude of the hemorheological parameters in the pathogenesis of arterial hypertension.