Cytokines profile and metabolic activity of neutrophils of peripheral blood when progressing neoplasma

Abstract

The neutrophil is considered as the peculiar monocelled sekretorny gland realizing the effector potential including by secretion of soluble products — cytokines and for today. Influence of a tumor on functional activity of neutrophils depends on type, localization and a stage of its development. In our research dynamics of metabolic and of neutrophils of peripheral blood, the contents in a lysate and serums of blood of cytokines of IL-1b, 1Ra, 2, 6, 10, 18, TNF-a, IFN-g and is studied when progressing a cervical cancer. Cytokines and metabolism indicators — activity of , determined by an immunofermental method, level of cationic proteins, a share of active cages in the spontaneous NST-test were cytochemical. It is shown that when progressing cervical cancer against increase in total of neutrophils significant decrease in their , aerobic and anaerobic bacterial action, decrease in the IL-1b and IL-1 Ra level, and also IFN-g takes place at TNF-a increase, increase of production of matrix metalloproteinas-2 on Ib—IIa of a stage of a disease that allows to assume emergence at this stage of cervical cancer of pro-tumoral effect of neutrophils.