Effect of lumbar (perirenal) procaine blockade on microcirculation and exchange proteoglycans with experimental gonarthrosis

Abstract

Experimental studies on guinea pigs of both sexes (n = 30). Experimental animals are divided into equal groups of 10 animals: 1 — the control group (intact animals), 2 — the comparison group (modelling of gonarthrosis by crossing his own patellar ligament has been made, exposure 6 months), 3 — the main group (animals with gonarthrosis treatment was carried out by performing lumbar procaine blockade (LPB) with an interval of 3—5 days three times). We establish that after a course of LPB in gonarthrosis marked increase in the density of the injected channel in the articular and periarticular structures, which reflects a growth in the microcirculation, and more intense accumulation in the basic substance of epiphyseal cartilage PAS (+) indicates the material to increase the level of proteoglycan in articular cartilage.