Experimental models of hepatocellular failure based on the isolated and combined effects of etiological factors

Abstract

Liver diseases remain one of the leading causes of mortality worldwide. The presence of multiple etiological factors in patients poses a particular challenge, often resulting in the development of combined liver injuries. This highlights the growing need for experimental models that simulate such combined hepatic damage. These models allow for the reproduction of metabolic, toxic, and infectious effects in conditions that closely resemble clinical reality. Currently, both in vitro and in vivo models are used for this purpose, each offering specific advantages and limitations. This article provides an overview of existing experimental models of combined liver injury, as well as isolated forms, which serve as a basis for studying pathogenesis and developing effective therapeutic strategies.