Signaling mechanism of neuroprotective effect of ischemic preconditioning of brain

Authors

  • L.N. Maslov Scientific Research Institute of Cardiology of SB of RAMS, 111a, Kievskaja str., Tomsk, 634012, Russia; Tomsk State Pedagogical University, 60, Kievskaya str., Tomsk, 634061, Russia

Keywords:

brain, ischemia, reperfusion, preconditioning, signaling mechanism

Abstract

Analysis of published data indicates that Ras-protein and kinases PI3K, Akt, MEK1/2, ERK1/2, PKC, CaMKII are involved in the signaling mechanism of ischemic preconditioning. In addition, it is established that cyclooxigenase-2, NO-synthase and mitKATP-channel are involved in delayed preconditioning. Signaling mechanism of early ischemic preconditioning of brain is remained unstudied.

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Published

12-08-2013

Issue

Vol. 57 No. 3 (2013)

Section

Reviews

How to Cite

Maslov L. Signaling mechanism of neuroprotective effect of ischemic preconditioning of brain // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2013. VOL. 57. № 3. PP. 73–80.

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